Land:
Boston, USA
Studienpopulation:
15000 männliche Ärzte im Alter von mindestens 55 Jahren
Zielgrößen:
- KHK
- Krebs
- Augenerkrankungen
Studiendauer:
1998 bis voraussichtlich 2005
Design
doppeltblind, randomisiert, placebokontrolliert, 2 x 2 x 2 x 2 faktorielles Design
Untersuchung zur Primärprävention
Methoden
Mehrere Gruppen:
- 400 IU Vitamin E oder sein Placebo jeden zweiten Tag im Wechsel mit 50 mg Beta-Carotin bzw. Placebo
- 500 mg Vitamin C oder Placebo/Tag
- ein Multivitaminpräparat (Centrum Silver, Lederle) oder sein Placebo/Tag
Ergebnisse
Thai Otsuka Pharmaceutical Co.
Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials.
Royal College of Physicians of Edinburgh
Antioxidants in Prevention and Treatment of cardiovascular Disease
Christen W.G. et.al. (Article)
Design of Physicians’ Health Study II—A Randomized Trial of Beta-Carotene, Vitamins E and C, and Multi- vitamins, in Prevention of Cancer, Cardiovascular Disease, and Eye Disease, and Review of Results of Completed Trials.
Ann Epidemiol 2000;10:125–134.
Links zur Studie
HeartInfo.org
Can Beta-Carotene Prevent Heart Disease?
Medline
Hennekens C.H. and Eberlein K.
A randomized trial of aspirin and beta-carotene among U.S. physicians.
Prev Med 1985 Mar;14(2):165-8
No authors listed (Abstract)
Final report on the aspirin component of the ongoing Physicians' Health Study. Steering Committee of the Physicians' Health Study Research Group.
N Engl J Med 1989 Jul 20;321(3):129-35
Manson J.E. et.al.
Baseline characteristics of participants in the Physicians' Health Study: a randomized trial of aspirin and beta- carotene in U.S. physicians.
Am J Prev Med 1991 May-Jun;7(3):150-4
Cook N.R.et.al.
Beta-carotene supplementation for patients with low baseline levels and decreased risks of total and prostate carcinoma.
Cancer. 1999 Nov 1;86(9):1783-92.
Cook N.R. et.al.
Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physicians' Health Study (United States).
Cancer Causes Control 2000 Aug;11(7):617-26